Showing 9 registered airlines with a combined fleet of 109 airframes.
| Airline Name | ICAO / IATA | Fleet Size |
|---|---|---|
| AlpAvia | APP / AL | 2 |
| Arrow Panama | WAP | 0 |
| Cargo Three | CTW | 0 |
| Copa Airlines | CMP / CM | 99 |
| DHL Aero Expreso | DAE / D5 | 6 |
| Panavia | PVI | 0 |
| Parsa | PST | 0 |
| Uniworld Air Cargo | UCG / U7 | 2 |
| Wingo Panama | WWP | 0 |